Inability ofmenmutants ofEscherichia colito use trimethylamine-N-oxide as an electron acceptor
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چکیده
منابع مشابه
Trimethylamine N-Oxide as a Novel Therapeutic Target in CKD.
Patients with CKD are at an increased risk for the development of cardiovascular disease even beyond traditional risk factors. Although uremic toxins have been proposed as important contributors in the pathogenesis of cardiovascular and renal disease progression in CKD, the sources and the processes of generating these toxins arediverse. Perturbations of the intestinal microbiota composition in...
متن کاملMicrobial trimethylamine-N-oxide as a disease marker: something fishy?
Production of trimethylamine-N-oxide (TMAO) via the gut microbiota has recently been proposed as an important pathophysiological mechanism linking ingestion of 'unhealthy foods', such as beef (containing carnitine) and eggs (containing choline), and the development of atherosclerosis. Hence, TMAO has gained attention as a novel biomarker for cardiovascular disease. However, fish and seafood con...
متن کاملThe biosynthesis of trimethylamine-N-oxide.
Norris and Benoit (1) provided ‘good evidence that injected trimethylamine is converted in the rat to its N-oxide and excreted in the urine. Other mammals have been shown to have the ability to effect the same reaction (2, 3). In a preliminary communication (4), we have reported that hog liver microsomes will catalyze the oxidation of trimethylamine in vitro. The additional requirement for redu...
متن کاملStructural mechanism for bacterial oxidation of oceanic trimethylamine into trimethylamine N-oxide.
Trimethylamine (TMA) and trimethylamine N-oxide (TMAO) are widespread in the ocean and are important nitrogen source for bacteria. TMA monooxygenase (Tmm), a bacterial flavin-containing monooxygenase (FMO), is found widespread in marine bacteria and is responsible for converting TMA to TMAO. However, the molecular mechanism of TMA oxygenation by Tmm has not been explained. Here, we determined t...
متن کاملTrimethylamine N-Oxide: The Good, the Bad and the Unknown
Trimethylamine N-oxide (TMAO) is a small colorless amine oxide generated from choline, betaine, and carnitine by gut microbial metabolism. It accumulates in the tissue of marine animals in high concentrations and protects against the protein-destabilizing effects of urea. Plasma level of TMAO is determined by a number of factors including diet, gut microbial flora and liver flavin monooxygenase...
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ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 1984
ISSN: 0378-1097,1574-6968
DOI: 10.1111/j.1574-6968.1984.tb01244.x